Acute cardiac care & resuscitationRandomised controlled trial
EEG-guided early cessation of sedation and targeted temperature management (TTM) in patients after cardiac arrest: a feasibility and safety study
- non-randomised, controlled intervention study
Authors' conclusion
Early withdrawal of sedation is feasible and safe in patients with an early favourable EEG following cardiac arrest. The study was underpowered to detect possible differences in long-term neurological recovery.
Study context
- Population
- Adult patients admitted to the ICU with postanoxic encephalopathy after cardiac arrest and an early (<12 h) favourable EEG pattern
- Participants
- 40 adult patients
- Comparison
- intervention group vs control group
- Primary endpoint
- Duration of mechanical ventilation
Primary result
As reported in the abstract
P < 0.001
Secondary outcomes
ICU length of stay · reduced by more than 50% in the intervention group
P = 0.001
Total sedation time · reduced by more than 50% in the intervention group
P < 0.001
Neurological outcomes · 3 or 6 months
- No statistically significant differences in neurological outcomes at 3 or 6 months
Original publication
EEG-guided early cessation of sedation and TTM in patients after cardiac arrest: a feasibility and safety study. Resuscitation. Published 17 April 2026. doi:10.1016/j.resuscitation.2026.111101
Summarised from the published abstract; every number is checked against it