Heart failure & cardiomyopathiesSecondary analysis
Effect Modification of Remote Patient Management by Sex and Marital Status Among Patients With Heart Failure in Germany: Findings From the Extended Interdisciplinary Network Heart Failure Trial
- secondary analysis of the multicenter, randomized E-INH study
- Flexible parametric Royston-Parmar survival models
Authors' conclusion
These findings indicate that the benefits from the RPM strategy HeartNetCare-HF in patients discharged after hospitalization for acute systolic HF were modulated by sex and marital status, both individually and in combination. Future studies are needed to evaluate whether tailoring RPM interventions according to patient sex and marital status optimizes outcomes in patients with HF.
Study context
- Population
- Patients hospitalized with acute systolic heart failure (HF) and a left ventricular ejection fraction ≤40% between 2004 and 2007, with available marital status informationof 1022 randomized participants, provided information on marital status
- Participants
- 1,008 patients
- Comparison
- Remote patient management (RPM) versus usual care, by sex and marital status
Primary result
As reported in the abstract
All-cause death, 3-way interaction (RPM, sex, marital status) · 18 and 60 months
3-way interaction at 18 months
P =0.015
3-way interaction at 60 months
P =0.004
Further findings
| Outcome | adjusted hazard ratio (95% CI) | |
|---|---|---|
| All-cause death among married women · 18 and 60 months — RPM vs usual care · 18 months, married women | 0.32 (0.10–0.98) | |
| All-cause death among married women · 18 and 60 months — RPM vs usual care · 60 months, married women | 0.44 (0.22–0.88) | |
| 0.10.31310Adjusted hazard ratio (log scale) |
All-cause mortality · 60 months
- married women receiving RPM
- 28%
- unmarried men receiving usual care
- almost 60%
Baseline characteristics
- mean age
- 68±13 years
- women
- 28%
- married
- 63%
Original publication
Effect Modification of Remote Patient Management by Sex and Marital Status Among Patients With Heart Failure in Germany: Findings From the Extended Interdisciplinary Network Heart Failure Trial. Circ Popul Health Outcomes. Published 17 August 2026. doi:10.1161/circoutcomes.125.012770
Summarised from the published abstract; every number is checked against it