HypertensionSecondary analysis
Effect of a ketogenic diet, time-restricted eating, or alternate-day fasting on changes in ambulatory blood pressure: a sub-analysis of a randomized clinical trial
- Secondary analysis of a randomised controlled trial
- single-centre
- parallel-group
Authors' conclusion
Diets with different ketogenic potential aimed to weight loss have different effectiveness in reducing blood pressure. mADF was the best approach regardless of changes in body composition or ketone production.
Study context
- Population
- Adults with obesity (BMI >30 kg/m²)
- Participants
- 96 adults
- Comparison
- Early time-restricted eating (eTRE), lTRE, modified alternate-day fasting (mADF) and ketogenic diet (KD) vs standard Mediterranean diet
- Primary endpoint
- Changes in BP by 24-h ambulatory BP monitoring (ABPM)
- Follow-up
- Before and after the intervention
Primary result
As reported in the abstract
24-h ABPM parameters
- mADF showed greater changes, with improvements in most ambulatory blood pressure monitoring (ABPM) parameters
- lTRE showed some improvements; other groups showed no significant change
- Linear mixed model: mADF associated with improvement in 24-h SBP
Further findings
Anthropometric parameters
- Significant changes in all groups
Original publication
Effect of a ketogenic diet, time-restricted eating, or alternate-day fasting on changes in ambulatory blood pressure: a sub-analysis of a randomized clinical trial. Eur J Prev Cardiol. Published 5 September 2025. doi:10.1093/eurjpc/zwaf567
Summarised from the published abstract; every number is checked against it