Effect of Colchicine on Arterial Stiffness in Patients With Hypertension: The COlchicine HypERtENsion Trial (COHERENT)
Primary result · Change in carotid-femoral pulse wave velocity (cfPWV)Result — go to the resultBetween-group difference in ΔcfPWV −0.1 m/s 95% CI −0.5 to 0.3- randomized, double-blind, placebo-controlled trial
Authors' conclusion
Six months of colchicine did not affect arterial stiffness in pharmacologically treated hypertension without cardiovascular disease. Colchicine significantly decreased hsCRP.
Study context
- Population
- Adults with pharmacologically treated hypertension without cardiovascular diseaserandomized (75 per group) of 183 screened
- Participants
- 150 adults
- Comparison
- colchicine compared with placebo
- colchicinen = 75
- placebon = 75
- Primary endpoint
- Change in carotid-femoral pulse wave velocity (cfPWV)
- Follow-up
- Six months
Primary result
As reported in the abstract
Change in carotid-femoral pulse wave velocity (cfPWV)
Between-group difference in ΔcfPWV
−0.1 m/s
95% CI −0.5 to 0.3
P = 0.53
Colchicine vs placebo
between-group difference in ΔcfPWV −0.1 m/s (95% CI −0.5 to 0.3); P = 0.53
Secondary outcomes
| Outcome | Between-group difference in Δoffice systolic BP (mmHg) (95% CI) | P value | |
|---|---|---|---|
| Change in office systolic BP · six months | 5.7 (1.0–10.5) | P = 0.018 | |
| −5051015Difference, mmHg (linear scale) |
| Outcome | Between-group difference in % change in hsCRP (95% CI) | P value | |
|---|---|---|---|
| % change in hsCRP · six months | −39.8% (−59.1 to −11.4%) | P = 0.010 | |
| −100−50050Difference (linear scale) |
- Change in office systolic blood pressure (BP): decreased significantly more in the placebo group than in the colchicine group
- % change in hsCRP: decreased significantly in the colchicine group compared with the placebo group
Baseline characteristics
- Mean age (±8.0) years
- 64.5
- Female
- 53 (35.3%)
- Mean systolic blood pressure (±15.6) mmHg
- 137.6
Left ventricular mass index, cardiac biomarkers
- Left ventricular mass index or cardiac biomarkers did not differ between groups
Original publication
Effect of Colchicine on Arterial Stiffness in Patients With Hypertension: The COlchicine HypERtENsion Trial (COHERENT). Eur J Prev Cardiol. Published 16 October 2026. doi:10.
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Summarised from the published abstract; every number is checked against it