Coronary disease & ACSRandomised controlled trial
Effect of Colchicine on Coronary Plaque Stability in Acute Coronary Syndrome as Assessed by Optical Coherence Tomography: The COLOCT Randomized Clinical Trial
- Randomised controlled trial
- prospective
- single-centre
- double-blind
Authors' conclusion
Our findings suggested that colchicine resulted in favorable effects on coronary plaque stabilization at optical coherence tomography in patients with acute coronary syndrome.
Study context
- Population
- Patients with ACS aged 18 to 80 years with lipid-rich plaque (lipid pool arc >90°) on optical coherence tomography52 per group completed
- Participants
- 128 patients
- Comparison
- Colchicine vs placebo
- Primary endpoint
- Change in minimal fibrous cap thickness from baseline
- Follow-up
- 12-month follow-up
Primary result
Change in minimal fibrous cap thickness · 12 months
Difference
34.2 μm
95% CI 9.7–58.6
P = 0.006
By group
Colchicine vs Placebo
difference 34.2 μm (95% CI 9.7–58.6); P = 0.006
As reported in the abstract
Further findings
°
| Outcome | Colchicine | Placebo | difference (°) (95% CI) | P value | |
|---|---|---|---|---|---|
| Average lipid arc | −35.7 (95% CI −40.5° to −30.8°) | −25.2 (95% CI −30.6° to −19.9°) | −10.5 (−17.7° to −3.4°) | P = 0.004 | |
| Mean angular extension of macrophages | −14.0 (95% CI −18.0° to −10.0°) | −8.9 (95% CI −13.3° to −4.6°) | −6.0 (−11.8° to −0.2°) | P = 0.044 | |
| −20−10010Difference, ° (linear scale) |
Geometric mean ratio
| Outcome | Colchicine | Placebo | difference (95% CI) | P value | |
|---|---|---|---|---|---|
| High-sensitivity C-reactive protein | 0.3 (95% CI 0.2–0.5) | 0.6 (95% CI 0.4–1.0) | 0.5 (0.3–1.0) | P = 0.046 | |
| Interleukin-6 | 0.5 (95% CI 0.4–0.7) | 0.8 (95% CI 0.6–1.1) | 0.6 (0.4–0.9) | P = 0.025 | |
| Myeloperoxidase | 0.8 (95% CI 0.7–0.9) | 1.0 (95% CI 0.8–1.2) | 0.8 (0.6–1.0) | P = 0.047 | |
| −0.500.511.5Difference (linear scale) |
Original publication
Effect of Colchicine on Coronary Plaque Stability in Acute Coronary Syndrome as Assessed by Optical Coherence Tomography: The COLOCT Randomized Clinical Trial. Circulation. Published 21 August 2024. doi:10.1161/circulationaha.124.069808
Summarised from the published abstract; every number is checked against it