Acute cardiac care & resuscitationRandomised controlled trial
Effect of Delayed Remote Ischemic Preconditioning on Acute Kidney Injury and Outcomes in Patients Undergoing Cardiac Surgery: A Randomized Clinical Trial
- Randomised controlled trial
- prospective
- single-centre
- double-blind
Authors' conclusion
Among high-risk patients undergoing cardiac surgery, delayed RIPC significantly reduced the occurrence of AKI.
Study context
- Population
- Patients at high risk for acute kidney injury (AKI) scheduled for elective cardiac surgery requiring cardiopulmonary bypass
- Participants
- 509 patients
- Comparison
- Delayed remote ischemic preconditioning (RIPC) vs sham
- RIPCn = 254
- Controln = 255reference
- Primary endpoint
- Incidence of AKI
- Follow-up
- Within 7 days after cardiac surgery
Primary result
As reported in the abstract
Odds ratio
0.68
95% CI 0.47–1.00
P = 0.048
Events by treatment group
RIPC vs Control
OR 0.68 (95% CI 0.47–1.00); P = 0.048
Secondary outcomes
Perioperative myocardial injury (cardiac troponin T, CK-MB, NT-proBNP), ICU and hospital stay, nonfatal MI, stroke and all-cause mortality by day 90
- No significant between-group differences
Original publication
Effect of Delayed Remote Ischemic Preconditioning on Acute Kidney Injury and Outcomes in Patients Undergoing Cardiac Surgery: A Randomized Clinical Trial. Circulation. Published 25 September 2024. doi:10.1161/circulationaha.124.071408
Summarised from the published abstract; every number is checked against it