Heart failure & cardiomyopathiesRandomised controlled trial
Effect of exercise training in patients with chronotropic incompetence and heart failure with preserved ejection fraction: the TRAINING-HR randomized clinical trial
- Randomised controlled trial
- 1:1:1:1 randomisation
Authors' conclusion
Different supervised exercise training improved peakVO2, ChR, and KCCQ in patients with ChI HFpEF phenotype.
Study context
- Population
- Symptomatic (NYHA II–III/IV) patients with chronotropic incompetence heart failure with preserved ejection fraction (HFpEF) phenotype
- Participants
- 80 participants
- Comparison
- Supervised exercise training programmes vs non-supervised exercise recommendations
- Primary endpoint
- Change in peakVO2
- Follow-up
- 12 weeks
Primary result
As reported in the abstract
- Aerobic training (AT)/HRT vs exercise recommendations (ER)
- Δ + 4.0 (95% CI 2.9–5.1); P < 0.001
- AT/LRT vs ER
- Δ + 3.6 (95% CI 2.5–4.6); P < 0.001
- AT vs ER
- Δ + 2.9 (95% CI 1.9–4.0); P < 0.001
- AT/HRT vs AT
- Δ + 1.1 (95% CI 0.1–2.2); P = 0.046
Secondary outcomes
Chronotropic response (ChR) and Kansas City Cardiomyopathy Questionnaire (KCCQ)
- Supervised exercise improved ChR and KCCQ without statistical differences between groups
Original publication
Effect of exercise training in patients with chronotropic incompetence and heart failure with preserved ejection fraction: the TRAINING-HR randomized clinical trial. Eur J Prev Cardiol. Published 28 April 2025. doi:10.1093/eurjpc/zwaf269
Summarised from the published abstract; every number is checked against it