Coronary disease & ACSSecondary analysis
Effect of Percutaneous Coronary Intervention (PCI) on Health Status in Ischemic Left Ventricular Dysfunction
- Secondary analysis of the REVIVED-BCIS2 randomised trial
- prespecified secondary analysis
Authors' conclusion
PCI did not improve the hierarchical composite of death, HHF, and health status at 2 years. PCI improved KCCQ-OSS at 6 months, but this benefit was not sustained to 1- or 2-year follow-up.
Study context
- Population
- Severe ischemic LV dysfunction
- Participants
- 347 vs 353
- Comparison
- PCI plus optimal medical therapy (OMT) vs OMT alone
- PCIn = 347
- OMTn = 353reference
- Primary endpoint
- Hierarchical composite of:
- All-cause death
- Hospitalization for heart failure (HHF)
- KCCQ-OSS
- Follow-up
- 24 months
Primary result
As reported in the abstract
Win ratio
1.05
95% CI 0.88–1.26
P = 0.58
PCI vs OMT
win ratio 1.05 (95% CI 0.88–1.26); P = 0.58
Secondary outcomes
| Outcome | PCI | OMT | OR (95% CI) | P value | |
|---|---|---|---|---|---|
| KCCQ-OSS responders (key secondary) · 6 months | 54.1% | 40.7% | 1.96 (1.41–2.71) | P < 0.001 | |
| KCCQ-OSS deteriorators · 6 months | 25.2% | 31.4% | 0.69 (0.47–1.00) | P = 0.048 | |
| 0.20.5125Odds ratio (log scale) |
KCCQ-OSS responders or deteriorators · 12 or 24 months
- PCI did not impact KCCQ-OSS responders or deteriorators
Original publication
Effect of PCI on Health Status in Ischemic Left Ventricular Dysfunction. JACC Heart Fail. Published 8 April 2024. doi:10.1016/j.jchf.2024.03.010
Summarised from the published abstract; every number is checked against it