Heart failure & cardiomyopathiesMeta-analysis
Effect of Pulmonary Artery Pressure-Guided Management on Outcomes of Patients with Heart Failure Outside Clinical Trials: A Systematic Review and Meta-Analysis of Real-World Evidence with the CardioMEMS Heart Failure System
- Systematic review and meta-analysis of observational (non-RCT) studies
- pre/post comparison
- random-effects models
- 4 US, 4 European studies
4 single-arm, open-label industry studies and 4 real-world practice studies
Authors' conclusion
Heart failure management with CardioMEMS leads to lower PAP, improved functional status and quality of life, and decrease of HFHs at 1 year in patients receiving the device in a real-life, non-RCT setting.
Study context
- Population
- Adults with heart failure (HF) receiving CardioMEMS in a non-RCT setting
- Participants
- 3,306 adults · 8 studies
- Comparison
- Pulmonary artery pressure (PAP)-guided HF management with CardioMEMS: after vs before implantation
- Outcome
- HF hospitalization (HFH) rates
- Follow-up
- 1 year
Pooled result
HFH
Incidence rate ratio
0.39
CI 0.31–0.47
CardioMEMS vs Pre-implantation
IRR 0.39 (CI 0.31–0.47)
As reported in the abstract
Further pooled results
Change in PAP
- Significant decrease in systolic PAP
- −7.8 mmHg [−10.1 mmHg; −5.6 mmHg]
- Significant decrease in mean PAP
- −5.2 mmHg [−6.7 mmHg; −3.8 mmHg]
- Significant decrease in diastolic PAP
- −4.4 mmHg [−5.5 mmHg; −3.3 mmHg]
- random-effect models
New York Heart Association (NYHA) class I/II · 1 year after implantation
- Patients in NYHA class I/II
- 56% [43%; 67%]
EQ-5D-5L visual analogue scale · 1 year after implantation
- Significant improvement from baseline
- 7.2 [3.5; 10.9]
Original publication
Effect of Pulmonary Artery Pressure-Guided Management on Outcomes of Patients with Heart Failure Outside Clinical Trials: A Systematic Review and Meta-Analysis of Real-World Evidence with the CardioMEMS Heart Failure System. Eur J Heart Fail. Published 13 May 2025. doi:10.1002/ejhf.3687
Summarised from the published abstract; every number is checked against it