Heart failure & cardiomyopathiesCohort study
Effect of Seasonal Influenza and COVID-19 Vaccination on Severity and Long-Term Outcomes of Patients with Heart Failure Decompensations
- Multicentre cohort study
- 40 Spanish EDs
- consecutive patients
- adjusted analyses
- subgroup analyses (16 characteristics)
Authors' conclusion
In HF patients, seasonal influenza vaccination appears to be associated with less severe decompensation and lower 1-year mortality, while no firm conclusions can be drawn from the results of the present study regarding the benefits of COVID-19 vaccination. Full vaccination is associated with the greatest reduction in short- and long-term mortality.
Study context
- Population
- Consecutive patients with acute heart failure (HF) attended at 40 Spanish EDs, November–December 2022
- Participants
- 1,841 / 3,139 / 1,773 / 1,036
- Exposure
- Influenza, COVID-19 and full vaccination vs no vaccination
- Influenza vaccinationn = 1,841
- COVID-19 vaccinationn = 3,139
- Full vaccinationn = 1,773
- Nonen = 1,036reference
- Outcome
- Severity of HF decompensation (MEESSI scale, hospitalization, intensive care unit (ICU) admission, in-hospital mortality) and long-term all-cause mortality
- Follow-up
- 90 days and 1 year
Main finding
As reported in the abstract
In-hospital, 90-day and 1-year all-cause mortality
Full vaccination vs NoneHazard ratio (95% CI)
in-hospital mortality
0.638(0.479–0.851)
90-day mortality
0.702(0.592–0.833)
1-year mortality
0.815(0.713–0.931)
- Overall 90-day mortality
- 20.3%
- Overall 1-year mortality
- 34.4%
- 90-day mortality, influenza-vaccinated
- adjusted HR 0.831 (0.709-0.973) (95% CI)
- 1-year mortality, influenza-vaccinated
- adjusted HR 0.885 (0.785-0.999) (95% CI)
- 90-day mortality, COVID-19 vaccinated (HR, 95% CI); not decreased at 1 year
- 0.829 (0.702-0.980)
Observational data: associations, not effects.
Further findings
1-year mortality, by 16 patient characteristics (subgroup)
- Association of vaccination with long-term survival consistent across subgroups
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Effect of Seasonal Influenza and COVID-19 Vaccination on Severity and Long-Term Outcomes of Patients with Heart Failure Decompensations. Eur J Heart Fail. Published 24 September 2024. doi:10.1002/ejhf.3469
Summarised from the published abstract; every number is checked against it