Heart failure & cardiomyopathies
Effectiveness and Safety of Ivabradine in Chinese Patients with Chronic Heart Failure: An Observational Study
Authors' conclusion
Ivabradine treatment reduced HR and improved cardiac function and health-related quality of life in Chinese patients with chronic HF.
Study context
- Population
- Chinese patients with chronic heart failure (HF)
- Participants
- 1,003 patients
- Outcome
- Change from baseline in HR, measured by pulse counting
- Follow-up
- 1 and 6 months
Methodological detailsmulticentre, single-arm, post hoc analysis of angiotensin receptor-neprilysin inhibitor (ARNI) or beta-blocker combination
- Multicentre
- Single-arm
- Post hoc analysis of ARNI or beta-blocker combination
Main finding
As reported in the abstract
Mean HR decrease at 1 month (b.p.m.)
12.9
Mean HR decrease at 6 months (b.p.m.)
16.1
Observational data: associations, not effects.
Further findings
Kansas City Cardiomyopathy Questionnaire (KCCQ) clinical summary score (CSS) and overall summary score (OSS) improvement ≥5 points · Month 6
- KCCQ CSS improvement ≥5 points
- 72.1%
- KCCQ OSS improvement ≥5 points
- 74.1%
- Both P < 0.001
LVEF change from baseline · Month 6
- LVEF increase
- 12.1 ± 11.6
- P
- P < 0.001
New York Heart Association (NYHA) class · Month 6
- Improvement in NYHA class
- 66.7%
- P
- P < 0.001
- NYHA class III at month 6
- 13.5%
- NYHA class IV at month 6
- 2.1%
Serum brain natriuretic peptide (BNP) and NT-proBNP change
- BNP change
- −331.9 ng/L (−1238.6, −134.0)
- NT-proBNP change
- −1113.8 ng/L (−2202.0, −297.2)
- P
- P < 0.001
HR, NYHA and KCCQ with vs without ARNI or beta-blocker (post hoc subgroup)
- HR reductions and improvements in NYHA and KCCQ scores similar with and without ARNIs or beta-blockers
- Post hoc analysis
Safety
- Treatment-emergent adverse events (TEAEs) (498 events)
- 296 patients (29.5%)
- Ivabradine-related TEAEs (73 events)
- 55 patients (5.5%)
- Sinus bradycardia
- 7
- Photopsia
- 7
- Patients with TEAEs in ARNI and beta-blocker subgroups
- 21.9-35.6%
Original publication
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