Valvular & structural heart diseaseMeta-analysis
Effectiveness of aortic valve replacement in Heyde syndrome: a meta-analysis
- Systematic review and meta-analysis
- random-effects models
Authors' conclusion
Aortic valve replacement is associated with rapid recovery of the bleeding diathesis in Heyde syndrome and gastrointestinal bleeding cessation. Residual valve disease compromises clinical benefits.
Study context
- Population
- Heyde syndrome (AS, acquired von Willebrand syndrome and gastrointestinal bleeding) undergoing aortic valve replacement33 studies (n = 1054) + 11 studies (n = 300)
- Comparison
- Aortic valve replacement in Heyde syndrome
- Outcome
- Proportion with recovery of acquired von Willebrand syndrome at T1 (<24 h), T2 (24-72 h), T3 (3-21 days), T4 (4 weeks to 2 years) after aortic valve replacement; proportion with cessation of gastrointestinal bleeding
Pooled result
As reported in the abstract
Pooled proportion with recovery of acquired von Willebrand syndrome / gastrointestinal bleeding cessation
- Acquired von Willebrand syndrome recovery at T1
- 86% (95% CI, 79%-91%)
- Acquired von Willebrand syndrome recovery at T2
- 90% (74%-96%)
- Acquired von Willebrand syndrome recovery at T3
- 92% (84%-96%)
- Acquired von Willebrand syndrome recovery at T4
- 87% (67%-96%)
- Gastrointestinal bleeding cessation
- 73% (62%-81%)
Further pooled results
Residual aortic valve disease and recovery
| Comparison | RR (CI) | P value | |
|---|---|---|---|
| Residual aortic valve disease · acquired von Willebrand syndrome recovery | 0.20 (0.05–0.72) | P = 0.014 | |
| Residual aortic valve disease · gastrointestinal bleeding recovery | 0.57 (0.40–0.81) | P = 0.002 | |
| 0.050.21520Relative risk (log scale) |
Original publication
Effectiveness of aortic valve replacement in Heyde syndrome: a meta-analysis. Eur Heart J. Published 5 July 2023. doi:10.1093/eurheartj/ehad340
Summarised from the published abstract; every number is checked against it