Randomised controlled trial
Effectiveness of Global Registry of Acute Coronary Events (GRACE) risk score in patients admitted to hospital with non-ST elevation acute coronary syndrome (UKGRIS): parallel group cluster randomised controlled trial
- Cluster randomised controlled trial
- parallel group
Authors' conclusion
In adults presenting to hospital with suspected non-ST elevation acute coronary syndrome, the GRS did not improve adherence to guideline recommended management or reduce cardiovascular events at 12 months.
Study context
- Population
- Adults presenting with suspected non-ST elevation ACS to hospitals in England, 2017–201938 UK clusters
- Participants
- 3,050 adults
- Comparison
- GRACE risk score-guided management vs standard care
- GRSn = 1,440
- Standard caren = 1,610reference
- Primary endpoint
- Use of guideline recommended management; time to composite of CV death, non-fatal MI, new onset HF hospital admission and readmission for CV event
- Follow-up
- 12 months
Primary result
As reported in the abstract
GRS vs Standard careEstimate (95% CI)P value
uptake of guideline recommended processes
OR 1.16(0.70–1.92)
P = 0.56time to first composite cardiac event
HR 0.89(0.68–1.16)
P = 0.37Further findings
| Outcome | difference (95% CI) | |
|---|---|---|
| Baseline adjusted EQ-5D-5L utility · 12 months | −0.01 (−0.06 to 0.04) | |
| −0.1−0.0500.05Difference (linear scale) |
Duration of hospital admission · within 12 months
Duration of hospital admission · within 12 months
- Similar for GRS and standard care
Original publication
Effectiveness of GRACE risk score in patients admitted to hospital with non-ST elevation acute coronary syndrome (UKGRIS): parallel group cluster randomised controlled trial. BMJ. Published 14 June 2023. doi:10.1136/bmj-2022-073843
Summarised from the published abstract; every number is checked against it