Heart failure & cardiomyopathiesRandomised controlled trial
Effectiveness of Nurse-Coordinated, Digital-Supported Collaborative Care Model in Reducing Hospital Stay and Mortality Among Patients With Heart Failure: TIME-HF Cluster RCT India
- Cluster randomised controlled trial
- parallel-group
- 22 centres
- 1:1 randomisation of centres
- All participants except one completed 24 months of follow-up
Authors' conclusion
A nurse-coordinated, mobile health-supported collaborative care model for heart failure with reduced ejection fraction in India increased the number of days alive and out of hospital, raised the absolute probability of remaining out of hospital by 11.8 percentage points, and reduced all-cause mortality by 22%.
Study context
- Population
- Adults with HFrEF in India
- Participants
- 1,507 adults · 22 centres
- Comparison
- Nurse-coordinated, mHealth-supported collaborative care vs usual care
- Interventionn = 755
- Usual caren = 752reference
- Primary endpoint
- Days alive and out of the hospital (one-inflated β model)
- Follow-up
- 2 years
Primary result
Days alive and out of hospital · up to 730 days
Odds ratio
1.78
95% CI 1.42–2.23
By group
Intervention vs Usual care
OR 1.78 (95% CI 1.42–2.23)
As reported in the abstract
Secondary outcomes
| Outcome | Intervention | Usual care | Estimate | P value | |
|---|---|---|---|---|---|
| All-cause mortality · 2 years | 21.59% | 26.73% | RR 0.80 (95% CI 0.67–0.97) | ||
| All-cause mortality · 2 years · multivariable Cox model | HR 0.78 (95% CI 0.63–0.95) | P = 0.028 | |||
| 0.512Ratio (log scale) |
Original publication
Effectiveness of Nurse-Coordinated, Digital-Supported Collaborative Care Model in Reducing Hospital Stay and Mortality Among Patients With Heart Failure: TIME-HF Cluster RCT India. Circulation. Published 30 August 2026. doi:10.1161/circulationaha.126.082490
Summarised from the published abstract; every number is checked against it