Arrhythmias & electrophysiology
Effects of anticoagulation in patients with device-detected atrial fibrillation and multiple stroke risk factors: a win ratio analysis of the NOAH-AFNET 6 trial
Primary result · Win ratioResult — go to the resultWin ratio 0.87 95% CI 0.68–1.10Authors' conclusion
This hypothesis-generating win ratio analysis, integrating death, thrombotic events, and major bleeds with and without quality of life, did not find an advantage of anticoagulation with edoxaban over no anticoagulation in patients with DDAF. The most common events were death and major bleeding.
Study context
- Population
- Patients with device-detected AF (device-detected atrial fibrillation (DDAF)) and multiple stroke risk factors; age 77 ± 7 years, 947 (37%) women, median CHA2DS2-VA score 3 (IQR 3–4)
- Participants
- 2,534 patients1,605,280 win ratio pairs
- Comparison
- Edoxaban vs no anticoagulation
- Primary endpoint
- Win ratio, hierarchical: (1) all-cause death, (2) stroke, (3) systemic or pulmonary embolism/MI, (4) major bleeding
- Follow-up
- Median 21 months (IQR, 10-38)
Methodological detailsunmatched win ratio analysis, hypothesis-generating
- Unmatched win ratio analysis
- Hypothesis-generating
Primary result
Win ratio
Win ratio
0.87
95% CI 0.68–1.10
P = 0.23
Edoxabanvs Placebo
win ratio 0.87 (95% CI 0.68–1.10); P = 0.23
As reported in the abstract
- Undecided pairs
- 84.9%
- Decided comparisons won by edoxaban
- 46%
- Decided comparisons won by placebo
- 54%
Further findings
Win odds (accounting for undecided comparisons), edoxaban vs no anticoagulation
- Win odds 0.98 (95% CI 0.94-1.01)
- P = 0.23
Undecided pairs
- Undecided pairs (no clear winner)
- 84.9%
- Edoxaban won, of the remaining comparisons
- 46%
- Placebo won, of the remaining comparisons
- 54%
Original publication
Effects of anticoagulation in patients with device-detected atrial fibrillation and multiple stroke risk factors: a win ratio analysis of the NOAH-AFNET 6 trial. Eur Heart J Qual Care Clin Outcomes. Published 1 September 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →