Prevention & lipidsRandomised controlled trial
Effects of a personalized nutrition program on cardiometabolic health: a randomized controlled trial
- Randomised controlled trial
Authors' conclusion
Following a personalized diet led to some improvements in cardiometabolic health compared to standard dietary advice.
Study context
- Population
- Adults aged 41–70 years, generally representative of the average US population
- Participants
- 347 adults
- Comparison
- Personalized dietary program vs general dietary advice
- Personalized dietary program (PDP)n = 177
- Controln = 170reference
- Primary endpoint
- Serum LDL-C and TG concentrations
- Follow-up
- 18 weeks
Primary result
As reported in the abstract
Serum TG and LDL-C
Triglyceride (TG): significant reduction with PDP vs control, mean difference (mmol l-1)
−0.13; log-transformed 95% CI −0.07 to −0.01; P = 0.016
Secondary outcomes
Body weight, waist circumference, HbA1c, diet quality, microbiome (beta-diversity)
- Improvements, particularly in highly adherent PDP participants
- P < 0.05
BP, insulin, glucose, C-peptide, apolipoprotein A1 and B, postprandial TGs
- Did not differ between groups
Safety
Serious intervention-related adverse events
- No serious intervention-related adverse events reported
Original publication
Effects of a personalized nutrition program on cardiometabolic health: a randomized controlled trial. Nat Med. Published 8 May 2024. doi:10.1038/s41591-024-02951-6
Summarised from the published abstract; every number is checked against it