Heart failure & cardiomyopathiesRandomised controlled trial
Effects of Acute Phase Intensive Exercise Training in Patients With Acute Decompensated Heart Failure
- Randomised controlled trial
- multicentre
- 2:1 randomisation
Authors' conclusion
In patients with ADHF without physical frailty, in-hospital exercise-based CR led to significant improvements in 6MWD at 2 weeks after randomization without compromising safety.
Study context
- Population
- Patients hospitalised with acute decompensated HF without physical frailty
- Participants
- 91 patients
- Comparison
- Early in-hospital exercise-based cardiac rehabilitation vs standard care
- Interventionn = 59
- Controln = 32reference
- Primary endpoint
- Change in 6-minute walk distance (6MWD) from baseline to discharge
- Follow-up
- Discharge
Primary result
Change in 6MWD · baseline to discharge
Effect size
30.9 m
95% CI 4.8–57.0
P = 0.021
By group
As reported in the abstract
Secondary outcomes
Physical and cognitive function, physical activity, quality of life
- Favorable results with intervention
Safety
Safety outcomes
- Similar between groups, except greater reduction in B-type natriuretic peptide at 90 days postdischarge with intervention
Original publication
Effects of Acute Phase Intensive Exercise Training in Patients With Acute Decompensated Heart Failure. JACC Heart Fail. Published 22 January 2025. doi:10.1016/j.jchf.2024.11.006
Summarised from the published abstract; every number is checked against it