Effects of Aerobic Exercise on Cardiorespiratory Fitness and Cardiovascular Risk Factors in Long-Term Breast Cancer Survivors

doi:10.1016/j.jaccao.2025.04.006

Cardio-oncology & otherRandomised controlled trial

Effects of Aerobic Exercise on Cardiorespiratory Fitness and Cardiovascular Risk Factors in Long-Term Breast Cancer Survivors

JACC CardioOncolPublication date not resolved

Randomised controlled trial
2-arm
non-randomised cancer-naive comparison group

Authors' conclusion

Although aerobic exercise improves CRF in anthracycline-treated long-term BCS, the response was less than one-half that observed in cancer-naive subjects.

Study context

Population: Anthracycline-treated long-term breast cancer survivors (BCS) and cancer-naive women140 BCS, 69 cancer-naive

Comparison: BCS exercise vs BCS usual care vs Non-cancer
Non-cancern = 69
Primary endpoint: Cardiorespiratory fitness (Vo2peak)
Follow-up: Baseline to post-exercise intervention

Primary result

As reported in the abstract

Change in Vo2peak

BCS exercise1.2± 2.6 · mL·kg-1·min-1

BCS usual care0.01± 2.5 · mL·kg-1·min-1

Non-cancer2.6± 2.5 · mL·kg-1·min-1

Mean difference (95% CI)P value

BCS exercise vs BCS usual care

1.3(0.5–2.1)

P = 0.002

BCS exercise vs Non-cancer

−1.4(−2.2 to −0.5)

P = 0.003

Secondary outcomes

Outcome	Lower with BCS exercise ←→ Higher with BCS exercise	mean difference (95% CI)	P value
Subjective vitality		2.56 (1.22–3.90)	P < 0.001
Satisfaction with life		1.68 (0.43–2.93)	P = 0.009
	−2024Difference (linear scale)

CV risk factors (cardiometabolic biomarkers, body composition)

No changes in CV risk factors

Original publication

Effects of Aerobic Exercise on Cardiorespiratory Fitness and Cardiovascular Risk Factors in Long-Term Breast Cancer Survivors. JACC CardioOncol. doi:10.1016/j.jaccao.2025.04.006

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Summarised from the published abstract; every number is checked against it