Effects of Baroreflex Activation Therapy on Cardiac Function and Morphology
Authors' conclusion
BAT reduced systolic and diastolic BP and was associated with morphological and functional improvement of HFpEF.
Study context
- Population
- Patients with therapy-resistant hypertension (blood pressure (BP) ≥140/90 mmHg despite ≥3 antihypertensives incl. a diuretic) receiving baroreflex activation therapy (BAT), 2012–2016
- Participants
- 64 consecutive patients
- Exposure
- Before vs after BAT implantation, trHTN with vs without heart failure with preserved ejection fraction (HFpEF)
- HFpEFn = 28
- Without HFpEFn = 21reference
- Outcome
- Office BP before → after BAT
Methodological detailsbefore–after, consecutive patients
- Before–after
- Consecutive patients
Main finding
As reported in the abstract
| Group | BP before | BP after | P SBP | P DBP |
|---|---|---|---|---|
| HFpEF | 169 ± 5/86 ± 4 | 143 ± 4/77 ± 3 | P = 0.0019 | 0.0403 |
| Without HFpEF | 170 ± 5/95 ± 4 | 149 ± 6/88 ± 5 | P = 0.0019 | 0.0763 |
BP before
HFpEF169 ± 5/86 ± 4
Without HFpEF170 ± 5/95 ± 4
BP after
HFpEF143 ± 4/77 ± 3
Without HFpEF149 ± 6/88 ± 5
P SBP
HFpEFP = 0.0019
Without HFpEFP = 0.0019
P DBP
HFpEF0.0403
Without HFpEF0.0763
Observational data: associations, not effects.
Further findings
ECG parameters, whole population (before → after)
- Heart rate 74 ± 2 to 67 ± 2 min-1
- P = 0.0062
- QRS-time 96 ± 3 to 106 ± 4 ms
- P = 0.0027
- QTc-duration 422 ± 5 to 432 ± 5 ms
- P = 0.0184
- PQ duration virtually unchanged
Echocardiographic parameters, HFpEF (before → after)
- Posterior wall diameter 14.0 ± 0.5 to 12.7 ± 0.3 mm
- P = 0.0125
- LV mass 278.1 ± 15.8 to 243.9 ± 13.4 g
- P = 0.0203
- E' lateral 8.2 ± 0.4 to 9.0 ± 0.4 cm/s
- P = 0.0471
Echocardiographic parameters, without HF
- No significant changes
Original publication
Effects of Baroreflex Activation Therapy on Cardiac Function and Morphology. ESC Heart Fail. Published 5 July 2024. doi:10.
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