Effects of endurance exercise training on left ventricular structure in healthy adults: a systematic review and meta-analysis
- Systematic review and meta-analysis
- random-effects
- meta-regression
+2 more
- random-effects
- meta-regression
Authors' conclusion
Left ventricular structure is significantly increased following ET. Males, young and trained individuals, and ET interventions involving mixed training regimes elicit the greatest changes in LV structure.
Study context
- Population
- Healthy adults (>18 years) undergoing endurance training for ≥2 weeks
- Participants
- 1,908 adults · 82 studies
- Comparison
- Pre- vs post-endurance training
- Outcome
- LV mass (LVM), septal (IVSd) and posterior wall thickness (PWTd) and LV diameter (LVDd) in diastole
Pooled result
As reported in the abstract
LV structure (LVM, PWTd, IVSd, LVDd) after endurance training (ET)
ETSMD (95% CI)P value
LVM
0.444(0.361–0.527)
P < 0.001PWTd
0.234(0.159–0.309)
P < 0.001IVSd
0.237(0.159–0.316)
P < 0.001LVDd
0.249(0.173–0.324)
P < 0.001Further pooled results
Mediators of LV mass (LVM) change (meta-regression)
- Trained status, training type and age were the only mediators; greatest change in previously trained, mixed-type training, young (18-35 years) and middle-aged (36-55 years) vs untrained, interval-type training and older (>55 years)
Wall thickness and LVDd by sex
- Significant increase in wall thickness in males; similar LVDd augmentation in males and females
Left ventricular (LV) structure by trained status and training modality
- Trained individuals: increase in all LV structures; mixed-type training and rowing/swimming gave greatest increase in PWTd and LVDd
Original publication
Effects of endurance exercise training on left ventricular structure in healthy adults: a systematic review and meta-analysis. Eur J Prev Cardiol. Published 31 January 2023. doi:10.
Summarised from the published abstract; every number is checked against it