Cardio-oncology & otherRandomised controlled trial
Effects of exercise training on cardiac toxicity markers in women with breast cancer undergoing chemotherapy with anthracyclines: a randomized controlled trial
- Randomised controlled trial
Authors' conclusion
Exercise training was safe during chemotherapy and significantly improved cardiorespiratory fitness. No significant effects were seen on cardiac toxicity markers (LVEF or GLS) as compared to the usual care.
Study context
- Population
- Women with early-stage breast cancer receiving anthracycline-containing chemotherapy (4 cycles doxorubicin plus cyclophosphamide)
- Participants
- 93 women
- Comparison
- Exercise vs usual care (UC)
- Exercisen = 47
- UCn = 46reference
- Primary endpoint
- Change in LVEF
- Follow-up
- Baseline to end of anthracycline cycles
Primary result
As reported in the abstract
end of AC
No significant between-group difference in left ventricular ejection fraction (LVEF) change at end of AC
mean difference 0.7%; 95% CI −0.8, 2.3; P = 0.349
Secondary outcomes
| Outcome | difference (mL O2·kg-1·min-1) (95% CI) | P value | |
|---|---|---|---|
| Estimated peak VO2 · end of AC | 1.6 (0.06–3.1) | P = 0.041 | |
| Estimated peak VO2 · 3 months after AC | 3.1 (1.4–4.7) | P < 0.001 | |
| −20246Difference, mL O2·kg-1·min-1 (linear scale) |
Change in LVEF · 3 months after AC
- No significant between-group difference in LVEF change 3 months after AC
- 1.1%; 95% CI −0.5, 2.6; P = 0.196
Global longitudinal strain (GLS), other echocardiographic parameters, NT-proBNP, hs-TnT
- No between-group differences in the remaining secondary endpoints
Safety
Serious adverse events during supervised exercise training programme (SETP)
- No serious adverse events observed during SETP
Original publication
Effects of exercise training on cardiac toxicity markers in women with breast cancer undergoing chemotherapy with anthracyclines: a randomized controlled trial. Eur J Prev Cardiol. Published 28 February 2023. doi:10.1093/eurjpc/zwad063
Summarised from the published abstract; every number is checked against it