Acute cardiac care & resuscitationSecondary analysis
Effects of mild hypercapnia on myocardial injury among ST-elevation myocardial infarction patients after out-of-hospital cardiac arrest: a exploratory post-hoc study of the TAME trial
- Post-hoc exploratory study of the TAME trial
Authors' conclusion
Among STEMI patients of the TAME trial, myocardial injury, in-hospital mortality, and neurological outcome at six months were not modified by allocation to targeted mild hypercapnia.
Study context
- Population
- Comatose adults after out-of-hospital cardiac arrest (OHCA) diagnosed with acute myocardial infarction (AMI), with STelevation myocardial infarction (STEMI)of 1700 TAME patients (49%) diagnosed with AMI, 593 had STEMI (73%), troponin levels available for 562 STEMI patients (95%)
- Participants
- 810 adults
- Comparison
- targeted mild hypercapnia or normocapnia
- mild hypercapnian = 287
- normocapnian = 306reference
- Primary endpoint
- Myocardial injury assessed by peak hs-cTnT or cTnI levels during hospitalisation in STEMI patients
- Follow-up
- During hospitalisation
Primary result
As reported in the abstract
Ratio of geometric means
- cTnI
- 1.18 (95% CI 0.79–1.77)
- High-sensitivity cardiac troponin T (hs-cTnT)
- 1.20 (95% CI 0.88–1.63)
Secondary outcomes
| Outcome | mild hypercapnia | normocapnia | Relative Risk (95% CI) | |
|---|---|---|---|---|
| In-hospital mortality in STEMI patients | 39% | 40.5% | 0.97 (0.82–1.14) | |
| Favourable neurological outcome · six months | 44.3% | 48.5% | 1.09 (0.92–1.29) | |
| 0.512Relative risk (log scale) |
Lactate clearance · first 24 h
- No difference in lactate clearance according to treatment allocation
All outcomes in successful percutaneous coronary intervention (PCI) STEMI patients (subgroup)
- No significant differences in any outcomes according to treatment allocation
Original publication
Effects of mild hypercapnia on myocardial injury among ST-elevation myocardial infarction patients after out-of-hospital cardiac arrest: a exploratory post-hoc study of the TAME trial. Resuscitation. Published 21 January 2026. doi:10.1016/j.resuscitation.2026.110982
Summarised from the published abstract; every number is checked against it