HypertensionRandomised controlled trial
Effects of Sedentary Behavior Reduction on Blood Pressure in Desk Workers: Results From the RESET-BP Randomized Clinical Trial
- Randomised controlled trial
- parallel-arm
- blinded outcome assessment
Authors' conclusion
A 3-month intervention that decreased SB and increased standing by ≈1 hour during the work day was not effective for reducing BP.
Study context
- Population
- Desk workers aged 18 to 65 years with SBP 120 to 159 or diastolic BP (DBP) 80 to 99 mm Hg, off antihypertensive medications, <150 min/wk of moderate to vigorous physical activity
- Participants
- 271 workers
- Comparison
- Sedentary behavior (SB) reduction intervention vs no-contact control
- Primary endpoint
- Clinic-based resting SBP
- Follow-up
- 3 months
Primary result
Resting SBP change
Difference
−0.22 mm Hg
P = 0.808
As reported in the abstract
Further findings
| Outcome | Estimate | P value |
|---|---|---|
| Resting DBP change · 3 months · ±0.61 | difference 0.13 mm Hg | P = 0.827 |
| SB, standing and stepping (intervention vs control) — Intervention vs Control · SB; ±0.17 · changes mainly during work time and below the goal | difference −1.15 h/d | P < 0.05 |
| SB, standing and stepping (intervention vs control) — Intervention vs Control · standing; ±0.14 · changes mainly during work time and below the goal | difference 0.94 h/d | P < 0.05 |
| SB, standing and stepping (intervention vs control) — Intervention vs Control · stepping; ±2.4 · changes mainly during work time and below the goal | difference 5.4 min/d | P < 0.05 |
Ambulatory blood pressure (BP) and pulse wave velocity (PWV)
- Similarly null for ambulatory BP and PWV
Associations of SB and standing changes with DBP and carotid-femoral PWV
- Decrease in work-time SB vs reduction in resting DBP
- r=0.15, P=0.017
- Reduction in work-time SB vs unfavorable increase in PWV
- r=−0.19, P=0.006
- Increase in work-time standing vs unfavorable increase in PWV
- r=0.17, P=0.011
- Increase in nonwork-time standing vs favorable PWV
- r=−0.14, P=0.038
Original publication
Effects of Sedentary Behavior Reduction on Blood Pressure in Desk Workers: Results From the RESET-BP Randomized Clinical Trial. Circulation. Published 21 August 2024. doi:10.1161/circulationaha.123.068564
Summarised from the published abstract; every number is checked against it