Heart failure & cardiomyopathiesMeta-analysis
Effects of weight loss in heart failure patients with overweight and obesity: a systematic review and meta-analysis
- Systematic review and meta-analysis of cohort studies and randomised controlled trials
Authors' conclusion
WL improves the long-term rehospitalization (>3 months), quality of life, cardiac function, and exercise capacity in overweight and obese HF patients. Although overall WL is not proven effective, subgroup analysis shows that BS can reduce mortality.
Study context
- Population
- Overweight and obese patients with heart failure (HF)
- Participants
- 449,882 participants · 19 studies
- Comparison
- Weight loss vs no weight loss
- Outcome
- Mortality and rehospitalization
Pooled result
As reported in the abstract
- Weight loss (WL) did not reduce mortality and rehospitalization rates
Further pooled results
Quality of life
- Improved with WL
- P = 0.002
Cardiac function
- Improved with WL
- P = 0.0001
Exercise capacity
- Improved with WL
- P = 0.03
Death, by WL modality (subgroup)
- Bariatric surgery: reduced risk of death
- P < 0.00001
- Medication or exercise: not significantly associated with risk of death
- P = 0.18
- Unspecified modality or unintentional WL: higher mortality
- P < 0.00001
Rehospitalization, by time
- Short-term: not reduced
- P = 0.11
- Long-term: reduced
- P = 0.03
Original publication
Effects of weight loss in heart failure patients with overweight and obesity: a systematic review and meta-analysis. Eur J Prev Cardiol. Published 31 August 2023. doi:10.1093/eurjpc/zwad284
Summarised from the published abstract; every number is checked against it