Pulmonary vascular disease & thromboembolism

Efficacy and safety of catheter-based thrombectomy versus catheter-directed thrombolysis in acute pulmonary embolism

Am Heart JPublished Meta-analysis of prospective and retrospective studies

Authors' conclusion

When compared with performance goal for CDT based on historical studies, CBT was noninferior for all-cause mortality (6.0% vs 6.87%; P-valueNI < .001), non-inferior and superior for major bleeding (4.9% vs 11%; P-valueNI < .001 and P < .001 for superiority).

Study context

Population
Acute PE
Comparison
Catheter-based thrombectomy (CBT) vs performance goal for catheter-directed thrombolysis (CDT)
Outcome
All-cause mortality
Methodological detailscomparison with performance goal rates from a published network meta-analysis, non-inferiority
  • Comparison with performance goal rates from a published network meta-analysis
  • Non-inferiority

Pooled result

As reported in the abstract

P-valueNI < .001

Safety

Major bleeding · non-inferior

P-valueNI < .001

OutcomeP value
Major bleedingSuperiorP < 0.001

Original publication

Efficacy and safety of catheter-based thrombectomy versus catheter-directed thrombolysis in acute pulmonary embolism. Am Heart J. Published 17 April 2024. doi:10.1016/j.ahj.2024.03.009

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