Coronary disease & ACSRandomised controlled trial
Efficacy of computerised cognitive training in patients with coronary heart disease and mild cognitive impairment: a randomised controlled trial
- randomised active-control trial
- intention-to-treat analysis
- multiple imputation for missing data
- eight Chinese medical centres
- 1:1 randomisation
Authors' conclusion
The efficacy of multidomain adaptive CCT in this population is not superior to that of traditional CCT. Although adaptive CCT has a higher compliance rate and can bring more significant changes in brain structure.
Study context
- Population
- Patients with coronary heart disease (CHD) and mild cognitive impairment (MCI)randomised
- Participants
- 224 patients
- Comparison
- adaptive computerised cognitive training (CCT) vs traditional CCT
- adaptive CCTn = 112
- traditional CCTn = 112reference
- Primary endpoint
- Proportion with improved overall cognitive function (Basic Cognitive Ability Test (BCAT))
- Follow-up
- 12 weeks
Primary result
As reported in the abstract
Odds ratio
1.02
95% CI 0.51–2.05
P = 0.947
adaptive CCT vs traditional CCT
OR 1.02 (95% CI 0.51–2.05); P = 0.947
Secondary outcomes
| Outcome | adaptive CCT | traditional CCT | P value |
|---|---|---|---|
| Cognitive abilities vs baseline · 12 weeks | p=0.015 | p=0.016 | |
| Training compliance · better compliance in adaptive group · exploratory outcome | P = 0.009 | ||
| Grey-matter volume in left supplementary motor area, right precuneus and right superior parietal lobule · significantly increased in adaptive group · exploratory outcome | P family-wise error=0.004 |
Cognitive abilities vs baseline · 12 weeks
- Both groups showed improved cognitive abilities at 12 weeks versus baseline
Health-related quality of life (EuroQol-5 Dimensions Questionnaire-3-Level) · 12 weeks
- Adaptive CCT improved health-related quality of life compared with traditional CCT
Anxiety and depression symptoms
- both interventions showed positive trends in improving anxiety and depression symptoms
Original publication
Efficacy of computerised cognitive training in patients with coronary heart disease and mild cognitive impairment: a randomised controlled trial. Heart. Published 4 May 2026. doi:10.1136/heartjnl-2025-327472
Summarised from the published abstract; every number is checked against it