Randomised controlled trial
Electroencephalography-Guided Anesthesia and Delirium in Older Adults After Cardiac Surgery
- Randomised controlled trial
- parallel-group
- patient- and outcome assessor-blinded
- 4 Canadian hospitals
- stratified by hospital
Recruitment December 2016 to February 2022, follow-up until February 2023
Authors' conclusion
Among older adults undergoing cardiac surgery, EEG-guided anesthetic administration to minimize EEG suppression, compared with usual care, did not decrease the incidence of postoperative delirium.
Study context
- Population
- Adults ≥60 years undergoing cardiac surgery1,131 (99.2%) assessed for primary outcome
- Participants
- 1,140 adults
- Comparison
- EEG-guided anesthesia vs usual care
- EEG-guidedn = 567
- Usual caren = 573reference
- Primary endpoint
- Delirium
- Follow-up
- Postoperative days 1 through 5
Primary result
As reported in the abstract
postoperative days 1 to 5
Difference
0.05%
95% CI −4.57% to 4.67%
Events by treatment group
EEG-guided vs Usual care
difference 0.05% (95% CI −4.57% to 4.67%)
Secondary outcomes
Median total time with EEG suppression (intraoperative) · decrease with EEG-guided
difference (minute) 7.7 (10.6–4.7)
Median
| Outcome | EEG-guided | Usual care | difference (95% CI) |
|---|---|---|---|
| Median volatile anesthetic minimum alveolar concentration (intraoperative) · lower with EEG-guided | 0.66 | 0.80 | 0.14 (0.15–0.13) |
Median ICU and hospital length of stay
- No significant difference between groups in median ICU length of stay
- difference, 0 days [95% CI, −0.31 to 0.31]
- No significant difference between groups in median hospital stay
- difference, 0 days [95% CI, −0.94 to 0.94]
Safety
Medical complications
Intraoperative awareness
- No patients reported intraoperative awareness
Original publication
Electroencephalography-Guided Anesthesia and Delirium in Older Adults After Cardiac Surgery. JAMA. Published 9 July 2024. doi:10.1001/jama.2024.8144
Summarised from the published abstract; every number is checked against it