Heart failure & cardiomyopathies
Electronic health record characterization and outcomes of heart failure with preserved ejection fraction
Authors' conclusion
Different EHR-based HFpEF definitions identified cohorts with modest overlap and varying baseline characteristics. Yet, long-term risk for HFH and death were similarly high for cohorts identified among both populations undergoing echocardiography only or echocardiography and RHC.
Study context
- Population
- Patients undergoing echocardiography (some within 6 months of right heart catheterization (RHC)) at an academic referral centre, 2008–20189,263 with RHC
- Participants
- 116,499 patients
- Exposure
- Electronic health record (EHR)-based heart failure with preserved ejection fraction (HFpEF) screening strategies: International Classification of Diseases (ICD) codes vs H2FpEF score vs RHC wedge pressure
- Outcome
- Cumulative incident HF hospitalization (HFH) and death
- Follow-up
- 10 years
Methodological detailssingle academic referral centre, consecutive patients
- Single academic referral centre
- Consecutive patients
Main finding
As reported in the abstract
Heart failure hospitalization (HFH) cumulative incidence, echocardiography-only population
32% to 45%
HFH cumulative incidence, echocardiography and RHC population
43% to 52%
Risk of death, echocardiography-only population
54% to 56%
Risk of death, echocardiography and RHC population
52% to 57%
Observational data: associations, not effects.
Further findings
Baseline characteristics in RHC population
Female sex
AF
| Outcome | ICD-HFpEF | H2FpEF-HFpEF | RHC-HFpEF |
|---|---|---|---|
| Baseline characteristics, H2FpEF-HFpEF vs ICD-HFpEFValue = median age · years | 67 | 72 | |
| White | 64% | 78% | — not stated in the abstract |
| AF | 41% | 97% | — not stated in the abstract |
— not stated in the abstract
Overlap of HFpEF definitions
- Met ICD or H2FpEF definition
- 33,461 (29%)
- Met both ICD and H2FpEF criteria
- 5,310 (16%)
- RHC population meeting any HFpEF criteria
- 6,353 (69%)
- RHC population meeting all three criteria
- 783 (12%)
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →