Prevention & lipidsCross-sectional study
Elevated Lipoprotein(a) Is Highly Prevalent in Autoimmune or Inflammatory Disease
- Cross-sectional study
- electronic health records from 5 University of California Health Systems
Authors' conclusion
Individuals with AIIDs are more likely to have elevated Lp(a) (>50 mg/dL and >70 mg/dL). Further study of the relationship between inflammation and Lp(a) in this population is needed.
Study context
- Population
- Patients with at least 1 Lp(a) measurement, stratified by AIID diagnosis, atherosclerotic cardiovascular disease (ASCVD), or controls (without AIIDs or ASCVD)patients with at least 1 Lp(a) measurement · AIID 7,995 · ASCVD 8,633 · controls 34,741
- Participants
- 49,431 patients
- Exposure
- AIID vs controls
- AIIDn = 7,995
- ASCVDn = 8,633
- controlsn = 34,741
Main finding
Lp(a) >50 mg/dL
Adjusted odds
1.22
95% CI 1.15–1.29
P < 0.001
Events by group
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | AIID | ASCVD | controls | adjusted odds (95% CI) |
|---|---|---|---|---|
| Lp(a) >70 mg/dL | 21.3% | Not reported in the abstract | 17.2% | |
| Characteristics of those with AIIDs | mean age 61.1 (SD 13.7) years | |||
| women | 45.7% | Not reported in the abstract | Not reported in the abstract | |
| White individuals | 66.9% | Not reported in the abstract | Not reported in the abstract | |
| Lp(a) >50 mg/dL by AIID (subgroup) — gout vs controls | 1.33 (1.23–1.44) | |||
| Lp(a) >50 mg/dL by AIID (subgroup) — inflammatory bowel disease vs controls | 1.26 (1.06–1.49) | |||
| Lp(a) >50 mg/dL by AIID (subgroup) — ankylosing spondylitis vs controls | 1.21 (1.09–1.34) |
- Lp(a) >70 mg/dL: P < 0.001
Lp(a) >50 mg/dL by AIID (subgroup)
- Prevalence of Lp(a) >50 mg/dL for AIIDs was between that of controls and those with ASCVD
Original publication
Elevated Lipoprotein(a) Is Highly Prevalent in Autoimmune or Inflammatory Disease. JACC Adv. doi:10.1016/j.jacadv.2026.103039
Summarised from the published abstract; every number is checked against it