Prevention & lipidsCohort study
Elevated lipoprotein(a) is not linked to coronary artery calcification incidence or progression
- Longitudinal cohort study
Authors' conclusion
Elevated Lp(a) levels were not associated with new-onset CAC or progression of existing CAC in this large longitudinal cohort.
Study context
- Population
- Adults aged ≥30 years with baseline Lp(a) measurement and coronary artery calcification (CAC) assessment by multi-detector CT, 2015–22
- Participants
- 41,929 adults
- Exposure
- Lp quintiles and clinical categories
- CAC = 0n = 32,338
- CAC > 0n = 9,591
- Outcome
- Incident CAC (CAC > 0) among those with CAC = 0; CAC progression among those with CAC > 0
- Follow-up
- Median 4.04 years (incidence); 3.78 years (progression)
Main finding
As reported in the abstract
Incident CAC (baseline CAC = 0) · median follow-up 4.04 years
Hazard ratio (95% CI)
Highest Lp(a) quintile vs Second quintile
0.998(0.90–1.10)
Lp(a) ≥100 mg/dL vs <30 mg/dL
0.83(0.57–1.23)
Observational data: associations, not effects.
Further findings
CAC progression (baseline CAC > 0) · median follow-up 3.78 years
- CAC progression did not differ materially across Lp(a) quintiles or clinical thresholds
Original publication
Elevated lipoprotein(a) is not linked to coronary artery calcification incidence or progression. Eur J Prev Cardiol. Published 3 April 2025. doi:10.1093/eurjpc/zwaf088
Summarised from the published abstract; every number is checked against it