Elevated lipoprotein(a) levels linked to new-onset atrial fibrillation: insights from a retrospective cohort study

doi:10.1093/eurjpc/zwaf063

Arrhythmias & electrophysiologyCohort study

Elevated lipoprotein(a) levels linked to new-onset atrial fibrillation: insights from a retrospective cohort study

Eur J Prev CardiolPublished 7 Feb 2025

Retrospective cohort study
3 Mayo Clinic sites

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Authors' conclusion

Our study suggests that elevated Lp(a) (≥50 mg/dL) is an independent risk factor for incident AF.

Study context

Population: Adults with baseline Lp(a) and no atrial fibrillation (AF) history, 3 Mayo Clinic sitesmedian follow-up 8.8 years
Participants: 75,376 adults

Exposure: High Lp vs low Lp
Outcome: Incident AF
Follow-up: Up to 15 years

Main finding

As reported in the abstract

Survival free from incident AF

High Lp(a)86%

Low Lp(a)88%

P < 0.001

Elevated Lp(a) and AF risk, multivariable-adjusted HR: 1.11 (1.05-1.18) (95% CI)

Observational data: associations, not effects.

Original publication

Elevated lipoprotein(a) levels linked to new-onset atrial fibrillation: insights from a retrospective cohort study. Eur J Prev Cardiol. Published 7 February 2025. doi:10.1093/eurjpc/zwaf063

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Summarised from the published abstract; every number is checked against it