Heart failure & cardiomyopathiesCohort study
Elevated Neutrophil-to-Lymphocyte Ratio Predicts Prognosis in Acute Myocarditis
- Retrospective cohort study
- multicentre
- 10 international tertiary referral cardiac centres
- consecutive patients
Authors' conclusion
In patients with AM, elevated NLR is associated with worse prognosis and may be valuable for stratifying patients, even those conventionally considered at low risk.
Study context
- Population
- Patients with acute myocarditis confirmed by CMR or endomyocardial biopsy
- Participants
- 1,150 patients
- Exposure
- Neutrophil-to-lymphocyte ratio (NLR) ≥4 vs NLR <4
- Outcome
- Composite of:
- All-cause mortality
- Heart transplantation
- Follow-up
- Median 228 weeks
Main finding
All-cause mortality or heart transplantation
Hazard ratio
3.03
95% CI 1.30–7.04
P = 0.010
NLR vs NLR <4
HR 3.03 (95% CI 1.30–7.04); P = 0.010
As reported in the abstract
- NLR ≥4 associated with worse prognosis
- P < 0.0001
Observational data: associations, not effects.
Further findings
All-cause mortality or heart transplantation, preserved EF at baseline (subgroup)
- Elevated NLR remained associated with worse outcomes
- P < 0.0001
Original publication
Elevated Neutrophil-to-Lymphocyte Ratio Predicts Prognosis in Acute Myocarditis. JACC Heart Fail. Published 22 January 2025. doi:10.1016/j.jchf.2024.11.003
Summarised from the published abstract; every number is checked against it