Cohort study
Elevated remnant cholesterol, plasma triglycerides, and cardiovascular and non-cardiovascular mortality
- Prospective cohort study
- population-based
Authors' conclusion
Remnant cholesterol of ≥1 mmol/L (39 mg/dL), present in 22% of the population, and plasma triglycerides of ≥2 mmol/L (177 mg/dL), present in 28% of the population, were associated with two-fold mortality from cardiovascular and other causes, but not from cancer.
Study context
- Population
- Individuals aged 20–69 years from the Copenhagen General Population Study, baseline 2003–2015
- Participants
- 87,192 individuals
- Exposure
- Remnant cholesterol ≥1.0 vs <0.5 mmol/L
- Outcome
- Mortality from CVD, cancer and other causes
- Follow-up
- Up to 13 years
Main finding
As reported in the abstract
Cause-specific mortality · up to 13 years
≥1.0 mmol/L vs <0.5 mmol/LHazard ratio (95% CI)
CVD mortality; multivariable-adjusted
2.2(1.3–3.5)
cancer mortality; multivariable-adjusted
1.0(0.7–1.3)
other-cause mortality; multivariable-adjusted
2.1(1.4–3.3)
- Deaths: CVD
- 687
- Deaths: cancer
- 1594
- Deaths: other causes
- 856
Observational data: associations, not effects.
Further findings
| Outcome | HR (CI) | |
|---|---|---|
| Cause-of-death subcategories (exploratory) — ≥1.0 mmol/L vs <0.5 mmol/L · ischemic heart disease · exploratory analysis | 4.4 (1.6–11) | |
| Cause-of-death subcategories (exploratory) — ≥1.0 mmol/L vs <0.5 mmol/L · infectious diseases · exploratory analysis | 8.4 (2.0–34) | |
| Cause-of-death subcategories (exploratory) — ≥1.0 mmol/L vs <0.5 mmol/L · endocrinological diseases · exploratory analysis | 9.1 (1.9–43) | |
| 0.050.21520Hazard ratio (log scale) |
Plasma TG >2 vs <1 mmol/L (>177 vs <89 mg/dL)
- Results similar to remnant cholesterol
Original publication
Elevated remnant cholesterol, plasma triglycerides, and cardiovascular and non-cardiovascular mortality. Eur Heart J. Published 12 January 2023. doi:10.1093/eurheartj/ehac822
Summarised from the published abstract; every number is checked against it