Coronary disease & ACSCohort study
Elevated Resting Coronary Blood Flow Is Associated With Death, MI, and HF in All-Comer Patients With Chronic Coronary Syndrome
- prospective observational study
Authors' conclusion
Elevated resting CBF in the left anterior descending coronary artery was associated with major adverse cardiovascular events in chronic coronary syndrome, whereas hyperemic microcirculatory resistance and flow were not.
Study context
- Population
- Patients with chronic coronary syndrome with and without obstructive coronary artery disease, included before undergoing coronary angiographypatients included in analyses, with 55 events
- Participants
- 410 patients
- Exposure
- Thermodilution-derived flow indices (index of microcirculatory resistance, baseline resistance index, resting coronary blood flow (CBF), hyperemic CBF) in the left anterior descending coronary artery and outcomes
- Outcome
- Primary composite outcome of:
- All-cause mortality
- Nonfatal myocardial infarction
- Heart failure hospitalization
- By resting CBF
- Follow-up
- Median 5.4 years
Main finding
As reported in the abstract
Resting CBF, hazard ratio
1.23 [95% CI 1.02-1.48]
Observational data: associations, not effects.
Further findings
Primary outcome by resting CBF, by revascularization (subgroup)
- Resting CBF in patients undergoing revascularization, hazard ratio
- 1.30 [95% CI 1.04-1.64]
- Resting CBF in patients not undergoing revascularization, hazard ratio
- 1.15 [95% 0.82-1.60]
- P interaction=0.771
Index of microcirculatory resistance and hyperemic CBF
- Neither the index of microcirculatory resistance nor hyperemic CBF were associated with outcomes
Death and nonfatal myocardial infarction by coronary microvascular dysfunction type
- Functional coronary microvascular dysfunction associated with a higher incidence vs no coronary microvascular dysfunction, log-rank
- P = 0.041
- Structural coronary microvascular dysfunction not associated
Original publication
Elevated Resting Coronary Blood Flow Is Associated With Death, MI, and HF in All-Comer Patients With Chronic Coronary Syndrome. Circ Cardiovasc Interv. Published 15 January 2026. doi:10.1161/circinterventions.125.015867
Summarised from the published abstract; every number is checked against it