Valvular & structural heart diseaseCohort study
End of Life After Transcatheter Aortic Valve Replacement
- Matched cohort study
- nationwide registers
- 1:10 matched on age, sex and calendar year of death
Authors' conclusion
End of life for TAVR patients is characterized by high frailty and comorbidity burden. Importantly, most hospitalizations are of noncardiovascular cause
Study context
- Population
- Deceased patients who underwent transcatheter aortic valve replacement (TAVR), Danish nationwide registers, 2008–2022median age 86 years, 55.1% males
- Participants
- 2,544 vs 25,440
- Exposure
- Deceased TAVR patients vs matched general-population controls
- TAVRn = 2,544
- Controlsn = 25,440reference
- Outcome
- Patient characteristics and hospitalizations at end of life
- Follow-up
- Last year of life
Main finding
As reported in the abstract
Hospitalization >28 days
Observational data: associations, not effects.
Further findings
Intermediate/high frailty
HF
CKD
Hospitalizations for noncardiovascular cause (of all hospitalizations) · last year of life
CV hospitalizations (of all hospitalizations) · last year of life
Hospitalizations for symptoms (of all hospitalizations) · last year of life
HF hospitalizations (of CV hospitalizations) · last year of life
- Hospitalizations for noncardiovascular cause (of all hospitalizations): of 6,943 vs 49,438 hospitalizations
Original publication
End of Life After Transcatheter Aortic Valve Replacement. JACC Cardiovasc Interv. Published 23 December 2024. doi:10.1016/j.jcin.2024.09.021
Summarised from the published abstract; every number is checked against it