Prevention & lipidsCohort study
Endometriosis and long-term cardiovascular risk: a nationwide Danish study
- Nationwide registry-based matched cohort study
- 1:4 matched controls (year of birth)
- nationwide registries
Authors' conclusion
Women with endometriosis have a higher associated long-term risk of cardiovascular outcomes compared with controls.
Study context
- Population
- Women in Danish nationwide registries; median age 37.3 yearsmatched cohort
- Participants
- 60,508 vs 242,032
- Exposure
- Endometriosis vs matched controls
- Endometriosisn = 60,508
- Controlsn = 242,032reference
- Outcome
- Composite of:
- Acute MI
- Ischaemic stroke
Main finding
As reported in the abstract
Endometriosis vs ControlsHazard ratio (95% CI)
unadjusted
1.18(1.14–1.23)
adjusted
1.15(1.11–1.20)
Observational data: associations, not effects.
Secondary outcomes
| Outcome | HR (95% CI) | |
|---|---|---|
| Arrhythmias — Endometriosis vs Controls · unadjusted | 1.24 (1.20–1.28) | |
| Arrhythmias — Endometriosis vs Controls · adjusted | 1.21 (1.17–1.25) | |
| HF — Endometriosis vs Controls · unadjusted | 1.16 (1.09–1.22) | |
| HF — Endometriosis vs Controls · adjusted | 1.11 (1.05–1.18) | |
| Mortality — Endometriosis vs Controls · unadjusted | 0.95 (0.92–0.97) | |
| Mortality — Endometriosis vs Controls · adjusted | 0.93 (0.91–0.96) | |
| 0.512Hazard ratio (log scale) |
Original publication
Endometriosis and long-term cardiovascular risk: a nationwide Danish study. Eur Heart J. Published 2 September 2024. doi:10.1093/eurheartj/ehae563
Summarised from the published abstract; every number is checked against it