Pulmonary vascular disease & thromboembolismCohort study
Endometriosis and long-term risk of venous thromboembolism: a Danish nationwide study
- Registry-based cohort study
- nationwide
- matched 1:4 on birth and index year
Authors' conclusion
Endometriosis was associated with an increased long-term risk of VTE compared with a matched background population.
Study context
- Population
- Danish women with endometriosis and matched background-population controlsmatched cohort
- Participants
- 63,999 vs 255,996
- Exposure
- Endometriosis vs matched women without endometriosis
- Endometriosisn = 63,999
- Controlsn = 255,996reference
- Outcome
- Venous thromboembolism (VTE) (composite of DVT and PE)
Main finding
As reported in the abstract
VTE
Endometriosis
2.18 per 1000 person-years
incidence rate · 95% CI 2.10–2.26
Controls
1.54 per 1000 person-years
incidence rate · 95% CI 1.51–1.58
Endometriosis vs ControlsHazard ratio (95% CI)
unadjusted
1.43(1.36–1.50)
adjusted for comorbidities and hormonal contraception
1.52(1.42–1.63)
Observational data: associations, not effects.
Secondary outcomes
DVT alone
- Adjusted HR
- 1.50 (95% CI 1.38-1.63)
PE alone
- Adjusted HR
- 1.52 (95% CI 1.36-1.70)
Original publication
Endometriosis and long-term risk of venous thromboembolism: a Danish nationwide study. Eur Heart J. Published 8 August 2026. doi:10.1093/eurheartj/ehag615
Summarised from the published abstract; every number is checked against it