Coronary disease & ACSRandomised controlled trial
Endotype-informed therapy and effects on illness perception and psychological health in patients with chest pain and no obstructive coronary artery disease
- prospective, multicentre, randomized controlled superiority trial
Authors' conclusion
In patients with ANOCA, non-invasive CMR-guided endotyping linked to targeted therapy resulted in substantial and sustained improvements in illness perception and psychological health, highlighting the importance of diagnostic clarification in addressing the psychological burden of this condition.
Study context
- Population
- Patients with chest pain undergoing invasive coronary angiography showing no obstructive coronary artery disease (ANOCA)randomized, mean age 63.3 years, 50.4% female · control 126 · intervention 124
- Participants
- 250 patients
- Comparison
- intervention vs control
- interventionn = 124
- controln = 126
Primary result
Brief Illness Perception Questionnaire (BIPQ) score (illness perception) · 6 months
Adjusted mean difference
−8.67
95% CI −12.04 to −5.30
P < 0.001
intervention vs control
adjusted mean difference −8.67 (95% CI −12.04 to −5.30); P < 0.001
As reported in the abstract
Further findings
| Outcome | adjusted mean difference (95% CI) | P value | |
|---|---|---|---|
| BIPQ score (illness perception) · 12 months · lower in intervention | −10.80 (−14.27 to −7.33) | P < 0.001 | |
| PHQ-4 score (psychological health) · 6 months · reduced in intervention | −0.88 (−1.19 to −0.57) | P < 0.001 | |
| PHQ-4 score (psychological health) · 12 months · reduced in intervention | −0.97 (−1.29 to −0.65) | P < 0.001 | |
| −20−10010Difference (linear scale) |
Original publication
Endotype-informed therapy and effects on illness perception and psychological health in patients with chest pain and no obstructive coronary artery disease. Eur Heart J Qual Care Clin Outcomes. Published 4 June 2026. doi:10.1093/ehjqcco/qcag081
Summarised from the published abstract; every number is checked against it