Enhancing invasive coronary function testing: Multivessel assessment of coronary microvascular dysfunction in patients with angina and no obstructive coronary artery disease (ANOCA)
Authors' conclusion
Among ANOCA patients ICFT with multivessel CFR assessment identified an additional 10% of patients with CMD only seen in the LCx. Future studies are needed to elucidate the role of multivessel CMD assessment in the management of patients with ANOCA.
Study context
- Population
- Patients with angina and no obstructive coronary artery disease (ANOCA) who underwent invasive coronary function testing (ICFT) in both the proximal LAD and the left circumflex (LCx) for assessment of coronary flow reserve (CFR)ANOCA patients included in this analysis
- Participants
- 231 patients
- Exposure
- Multivessel coronary microvascular dysfunction (CMD) vs single vessel CMD
- Outcome
- Additional patients with CMD (CFR ≤ 2.5) identified by multivessel CFR assessment that would have been missed by LAD assessment only
Methodological detailsconsecutive ICFT using the Doppler method
- Consecutive ICFT using the Doppler method
Main finding
As reported in the abstract
Additional patients with CMD identified
10%
Observational data: associations, not effects.
Further findings
| Outcome | Multivessel CMD | Single vessel CMD | P value |
|---|---|---|---|
| CFR in the LADStatistically significant lower CFR with multivessel CMD | 1.9 | 2.7 | P < 0.001 |
| CFR in the LCxStatistically significant lower CFR with multivessel CMD | 1.9 | 2.4 | P < 0.001 |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Enhancing invasive coronary function testing: Multivessel assessment of coronary microvascular dysfunction in patients with angina and no obstructive coronary artery disease (ANOCA). Am Heart J. Published 21 March 2026. doi:10.
Summarised from the published abstract; every number is checked against it