Heart failure & cardiomyopathies
Epigenetic Regulation of Cardiomyocyte Maturation by Arginine Methyltransferase CARM1
Authors' conclusion
This study establishes a critical and multifaceted role for CARM1 in regulating cardiomyocyte maturation and demonstrates that deregulation of CARM1-dependent cardiomyocyte maturation gene expression may contribute to human heart diseases.
Study context
- Population
- Neonatal cardiomyocytes (mosaic knockout model)
- Comparison
- Mosaic Carm1 ablation vs intact Carm1 in cardiomyocytes
- Outcome
- Cardiomyocyte maturation after mosaic Carm1 ablation
Methodological detailsin vivo mosaic knockout
- In vivo mosaic knockout
Main finding
As reported in the abstract
- Reduced cardiomyocyte size and sarcomere thickness (cell autonomous)
- Severe loss and disorganization of T tubules
- Compromised electrophysiological maturation
- CARM1 directly activates genes underlying cytoarchitectural and electrophysiological maturation
- Significant enrichment of human heart disease-associated SNPs in region syntenic to H3R17me2a ChIP-seq peaks
Original publication
Epigenetic Regulation of Cardiomyocyte Maturation by Arginine Methyltransferase CARM1. Circulation. Published 15 January 2024. doi:10.
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