Cardiometabolic & kidneyMeta-analysis
Erythrocyte odd-chain fatty acids and the risk of cardiometabolic diseases: a prospective study and updated meta-analysis
- Prospective cohort study and updated meta-analysis of prospective studies
Authors' conclusion
Our findings supported favorable associations between OCFAs and CMDs among populations with varied dietary sources and intake levels
Study context
- Population
- Adults in the 2nd resurvey of the China Kadoorie Biobank (CKB), 2013–14 (38% men, mean age 58.1 years)950 incident CMD
- Participants
- 8,185 adults
- Comparison
- Erythrocyte odd-chain fatty acid levels: top vs bottom tertile
- Outcome
- Incident cardiometabolic diseases (ischemic heart disease (IHD), diabetes, stroke)
- Follow-up
- about 5-year follow-up
Pooled result
As reported in the abstract
Incident IHD, diabetes and total CMDs by erythrocyte 15:0 and 17:0 (CKB)
Hazard ratio (95% CI)
15:0 top tertile vs bottom tertile
0.72(0.59–0.89)
17:0 top tertile vs bottom tertile
0.69(0.56–0.86)
- 17:0 inversely associated with incident diabetes, HR
- 0.41 [0.27-0.62]
- 17:0 inversely associated with total cardiometabolic diseases (CMDs), HR
- 0.85 [0.74-0.97]
Further pooled results
| Outcome | pooled RR (CI) | |
|---|---|---|
| Diabetes and IHD, updated meta-analysis (33 additional prospective studies, 112,193 participants) — 15:0 · diabetes, per 10th-90th percentile range | 0.74 (0.68–0.80) | |
| Diabetes and IHD, updated meta-analysis (33 additional prospective studies, 112,193 participants) — 17:0 · diabetes, per 10th-90th percentile range | 0.65 (0.61–0.71) | |
| Diabetes and IHD, updated meta-analysis (33 additional prospective studies, 112,193 participants) — 17:0 vs Bottom tertile · incident IHD | 0.87 (0.77–0.97) | |
| 0.512Pooled relative risk (log scale) |
Dietary correlates of odd-chain fatty acids (OCFAs) (CKB)
- OCFAs significantly correlated with intakes of dairy products, wheat and coarse grains, and fish/seafood
Original publication
Erythrocyte odd-chain fatty acids and the risk of cardiometabolic diseases: a prospective study and updated meta-analysis. Eur J Prev Cardiol. Published 24 September 2025. doi:10.1093/eurjpc/zwaf601
Summarised from the published abstract; every number is checked against it