Estimating the Prevalence of Hypercholesterolemia in Indigenous Populations: A Systematic Review and Meta-Analysis
Authors' conclusion
Hypercholesterolemia is prevalent in Indigenous communities and may contribute to the high burden of ASCVD these populations face.
Study context
- Population
- Indigenous populations in Canada, the US, Australia and New Zealand
- Outcome
- Prevalence of hypercholesterolemia, severe hypercholesterolemia and FH
Methodological detailsrandom-effects model, meta-regression
- Random-effects model
- Meta-regression
Pooled result
As reported in the abstract
Pooled prevalence of hypercholesterolemia in Indigenous populations
Pooled prevalence of hypercholesterolemia (all diagnostic criteria), ∼1 in 3 to 1 in 4 individuals; 95% CI 22.4%-36.4%
28.9%
Pooled prevalence using LDL-C cutoff ≥3.5 mmol/L (135 mg/dL); 95% CI 7.7%-19.9%
12.6%
Further pooled results
Percent
North America
24.3%(95% CI 17.1%–33.3%)
Australia
40.0%(95% CI 31.3%–49.3%)
Meta-regression: effect of diabetes on prevalence
- DM had a significant effect on prevalence
- P = 0.022
Original publication
Estimating the Prevalence of Hypercholesterolemia in Indigenous Populations: A Systematic Review and Meta-Analysis. JACC Adv. Published 26 May 2023. doi:10.
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