Cardio-oncology & otherCohort study
Estimating the Proportion of Adverse Pregnancy Outcomes Prevented With Improved Early Pregnancy Cardiovascular Health
- cohort
Authors' conclusion
In this cohort of nulliparous pregnant individuals, potential benefits of improving maternal CVH to reduce APOs are considerable.
Study context
- Population
- Pregnant participants ≥18 years and without prepregnancy hypertension or gestational diabetes from the Nulliparous Pregnancy Outcomes Study
- Participants
- 8,927 participants
- Exposure
- Association of early pregnancy cardiovascular health (CVH) and adverse pregnancy outcomes (APOs); impact fractions for hypothetical improvement of maternal CVH
Main finding
As reported in the abstract
APO risk per lower CVH score
adjusted OR (lower CVH score, higher APO risk)
1.46; 95% CI: 1.39-1.54
Observational data: associations, not effects.
Further findings
Proportion of APOs prevented, CVH score <50 shifted to 50 points (5.8% of participants)
- APOs prevented
- 12%
- hypothetical intervention
Proportion of APOs prevented, CVH score <80 shifted to 80 points (51.4% of participants)
- APOs prevented
- 15%
- hypothetical intervention
- dose-response relationship
Proportion of APOs prevented, everyone shifted to 100 points (96.6% of participants)
- APOs prevented
- 40%
- hypothetical intervention
- dose-response relationship
APO subtypes
- Similar findings were observed for each APO subtype
Participant characteristics
- age
- 27.2 years (SD: 5.4)
- experienced an APO
- 25.3%
Original publication
Estimating the Proportion of Adverse Pregnancy Outcomes Prevented With Improved Early Pregnancy Cardiovascular Health. JACC Adv. Published 17 January 2026. doi:10.1016/j.jacadv.2025.102501
Summarised from the published abstract; every number is checked against it