Arrhythmias & electrophysiologyCohort study
Ethnic differences in clinical outcomes following major bleeding in atrial fibrillation patients: a report from two prospective regional registries in Europe and Asia
- Analysis of two prospective registries
- multicentre
- Europe and Asia
Authors' conclusion
Following MB, East Asian patients with AF might be more susceptible to MACE and thromboembolism when compared to Europeans.
Study context
- Population
- Patients with atrial fibrillation (AF) in the Asian-Pacific Heart Rhythm Society (APHRS) and EURObservational Research Programme (EORP) registries; ethnicity inferred by enrolment country597 with prior major bleeding (MB) (3.8%)
- Exposure
- Prior MB vs No MB
- Prior MBn = 597
- Outcome
- All-cause mortality and MACE
Main finding
MACE
Hazard ratio
0.98
95% CI 0.72–1.33
Prior MB vs No MB
HR 0.98 (95% CI 0.72–1.33)
As reported in the abstract
Observational data: associations, not effects.
Further findings
Thrombo-embolic events
- Prior MB vs no MB, entire population (not significant)
- HR 0.87, 95% CI 0.46-1.65
- More pronounced in East Asians vs Europeans
- P for interaction = 0.004
Oral anticoagulants (OAC) use
- History of MB associated with lower OAC use
- OR 0.44, 95% CI 0.35-0.54
VKA use
- History of MB associated with lower VKA use
- OR 0.73, 95% CI 0.59-0.90
Clinical characteristics
- Patients with prior MB older, more commonly East Asian, higher CV burden than those without MB
Original publication
Ethnic differences in clinical outcomes following major bleeding in atrial fibrillation patients: a report from two prospective regional registries in Europe and Asia. Eur J Prev Cardiol. Published 18 August 2025. doi:10.1093/eurjpc/zwaf489
Summarised from the published abstract; every number is checked against it