Ethnicity and its impact on presentation and outcomes in patients with spontaneous coronary artery dissection from the Australian-New Zealand registry
Authors' conclusion
This study is the first to describe the diverse ethnic distribution of patients with SCAD in the Australian-New Zealand-SCAD registry. Important ethnic differences include higher rates of pregnancy-SCAD in MENAA patients, and higher rates of bystander atherosclerosis in First Nations and Pacific Peoples patients. No ethnic difference was seen in MACE-free survival following SCAD.
Study context
- Population
- Adult patients with acute coronary syndrome (ACS) and core-laboratory confirmed spontaneous coronary artery dissection (SCAD) from 23 hospitals in Australia and New Zealandpatients with SCAD · white 488 · Asian 45 · Middle Eastern, North African, African (MENAA) 29 · First Nations and Pacific Peoples 48 · Other 12
- Participants
- 622 patients
- Exposure
- Ethnic differences in major adverse cardiovascular events
- Whiten = 488
- Asiann = 45
- MENAAn = 29
- First Nations and Pacific Peoplesn = 48
- Outcome
- Pregnancy-associated SCAD
Methodological details23 hospitals in Australia and New Zealand, core-laboratory confirmed SCAD
- 23 hospitals in Australia and New Zealand
- Core-laboratory confirmed SCAD
Main finding
As reported in the abstract
P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | Asian | MENAA | First Nations and Pacific Peoples | P value |
|---|---|---|---|---|
| Chest painMENAA vs overall · lower in MENAA | — not stated in the abstract | 86% | — not stated in the abstract | P = 0.008 |
| Bystander atherosclerosisFirst Nations and Pacific Peoples vs overall · higher in First Nations and Pacific Peoples | — not stated in the abstract | — not stated in the abstract | 25% | P = 0.02 |
| Non-fibromuscular dysplasia extracardiac vascular abnormalitiesAsian vs overall · higher in Asian | 16% | — not stated in the abstract | — not stated in the abstract | P = 0.008 |
— not stated in the abstract
- Chest pain: overall 96%
- Bystander atherosclerosis: overall 16%
- Non-fibromuscular dysplasia extracardiac vascular abnormalities: overall 5%
MACE-free survival
- MACE-free survival was similar across ethnic groups, and ethnicity was not an independent predictor of MACE when adjusted for potential confounders
- Cox proportional hazards models
Cohort characteristics
- Mean age
- 52.3±10.5 years
- Female
- 87.9%
Original publication
Ethnicity and its impact on presentation and outcomes in patients with spontaneous coronary artery dissection from the Australian-New Zealand registry. Heart. Published 20 April 2026. doi:10.
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