Coronary disease & ACSCohort study
Ethnicity and its impact on presentation and outcomes in patients with spontaneous coronary artery dissection from the Australian-New Zealand registry
- prospective and retrospective cohort study
- 23 hospitals in Australia and New Zealand
- core-laboratory confirmed spontaneous coronary artery dissection (SCAD)
Authors' conclusion
This study is the first to describe the diverse ethnic distribution of patients with SCAD in the Australian-New Zealand-SCAD registry. Important ethnic differences include higher rates of pregnancy-SCAD in MENAA patients, and higher rates of bystander atherosclerosis in First Nations and Pacific Peoples patients. No ethnic difference was seen in MACE-free survival following SCAD.
Study context
- Population
- Adult patients with acute coronary syndrome (ACS) and core-laboratory confirmed SCAD from 23 hospitals in Australia and New Zealandpatients with SCAD · white 488 · Asian 45 · Middle Eastern, North African, African (MENAA) 29 · First Nations and Pacific Peoples 48 · Other 12
- Participants
- 622 patients
- Exposure
- ethnic differences in major adverse cardiovascular events
- whiten = 488
- Asiann = 45
- MENAAn = 29
- First Nations and Pacific Peoplesn = 48
Main finding
As reported in the abstract
Pregnancy-associated SCAD
P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | white | Asian | MENAA | First Nations and Pacific Peoples | P value |
|---|---|---|---|---|---|
| Chest pain · lower in MENAA | Not reported in the abstract | Not reported in the abstract | 86% | Not reported in the abstract | P = 0.008 |
| Bystander atherosclerosis · higher in First Nations and Pacific Peoples | Not reported in the abstract | Not reported in the abstract | Not reported in the abstract | 25% | P = 0.02 |
| Non-fibromuscular dysplasia extracardiac vascular abnormalities · higher in Asian | Not reported in the abstract | 16% | Not reported in the abstract | Not reported in the abstract | P = 0.008 |
- Chest pain: overall 96%
- Bystander atherosclerosis: overall 16%
- Non-fibromuscular dysplasia extracardiac vascular abnormalities: overall 5%
MACE-free survival
- MACE-free survival was similar across ethnic groups, and ethnicity was not an independent predictor of MACE when adjusted for potential confounders
- Cox proportional hazards models
Cohort characteristics
- mean age
- 52.3±10.5 years
- female
- 87.9%
Original publication
Ethnicity and its impact on presentation and outcomes in patients with spontaneous coronary artery dissection from the Australian-New Zealand registry. Heart. Published 20 April 2026. doi:10.1136/heartjnl-2026-327842
Summarised from the published abstract; every number is checked against it