Arrhythmias & electrophysiologyCohort study
EUropean real-world outcomes with Pulsed field ablatiOn in patients with symptomatic atRIAl fibrillation: lessons from the multi-centre EU-PORIA registry
- Prospective multicentre registry
- 7 high-volume centres
- consecutive enrolment
- all-comer
Authors' conclusion
The EU-PORIA registry demonstrates a high single-procedure success rate with an excellent safety profile and short procedure times in a real-world, all-comer AF patient population.
Study context
- Population
- All-comer patients with symptomatic atrial fibrillation (AF) undergoing pulmonary vein (PV) isolation with the pentaspline multi-electrode pulsed field ablation (PFA) catheter42 operators
- Participants
- 1,233 patients
- Outcome
- Safety, efficacy and learning curve characteristics of the pentaspline PFA catheter
Main finding
As reported in the abstract
Arrhythmia-free survival (Kaplan-Meier estimate) · median follow-up 365 (323-386) days
Arrhythmia-free survival, all
74%
Arrhythmia-free survival, paroxysmal AF
80%
Arrhythmia-free survival, persistent AF
66%
Observational data: associations, not effects.
Further findings
Procedure and fluoroscopy times
min
- Median procedure time (IQR 40-87)
- 58
- Median fluoroscopy time (IQR 9-21)
- 14
- No differences due to operator experience
Additional lesions outside the PVs
- Patients with additional lesions outside the PVs
- 169 (14%)
- Posterior wall
- 127
Repeat procedure for AF recurrence
- Patients with repeat procedure
- 149 (12%)
- PVs durably isolated at repeat procedure
- 418/584 (72%)
Safety
Major complications
- Major complications
- 21/1233 (1.7%)
- Pericardial tamponade
- 14 (1.1%)
- TIA or stroke (one fatal)
- 7 (0.6%)
- Prior cryoballoon users had fewer complications
Original publication
EUropean real-world outcomes with Pulsed field ablatiOn in patients with symptomatic atRIAl fibrillation: lessons from the multi-centre EU-PORIA registry. Europace. Published 28 June 2023. doi:10.1093/europace/euad185
Summarised from the published abstract; every number is checked against it