Heart failure & cardiomyopathiesSecondary analysis
EuroQol 5-Dimension Questionnaire in Heart Failure With Reduced, Mildly Reduced, and Preserved Ejection Fraction
- Secondary analysis of the DAPA-HF and DELIVER randomised trials
- pooled patient-level analysis
Authors' conclusion
The EQ-5D revealed problems not often associated (eg, pain) with HF or commonly quantified in HF (eg, anxiety/depression). Dapagliflozin improved multiple QoL dimensions, and possibly anxiety/depression.
Study context
- Population
- Patients with heart failure (HF) with reduced, mildly reduced or preserved EF (DAPA-HF and DELIVER)10,135 (92.1%) completed EQ-5D
- Participants
- 11,007 patients
- Comparison
- EQ-5D-LSS categories
- Primary endpoint
- CV death or worsening HF (time to first event) by EQ-5D-LSS
Primary result
As reported in the abstract
CV death or worsening HF
Each group vs EQ-5D-LSS 5Hazard ratio (95% CI)
EQ-5D-LSS 6-10
1.27(1.10–1.47)
EQ-5D-LSS 11-15
1.70(1.46–1.98)
EQ-5D-LSS 16-25
2.31(1.88–2.85)
Further findings
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Improvement in EQ-5D dimensions with dapagliflozin · 8 months — Dapagliflozin vs EQ-5D-LSS 5 · mobility | 1.13 (1.04–1.23) | P = 0.004 | |
| Improvement in EQ-5D dimensions with dapagliflozin · 8 months — Dapagliflozin vs EQ-5D-LSS 5 · self-care | 1.13 (1.02–1.24) | P = 0.016 | |
| Improvement in EQ-5D dimensions with dapagliflozin · 8 months — Dapagliflozin vs EQ-5D-LSS 5 · usual activities | 1.11 (1.02–1.21) | P = 0.015 | |
| Improvement in EQ-5D dimensions with dapagliflozin · 8 months — Dapagliflozin vs EQ-5D-LSS 5 · anxiety/depression | 1.10 (1.01–1.21) | P = 0.034 | |
| 0.512Odds ratio (log scale) |
- Improvement in EQ-5D dimensions with dapagliflozin — NNT for 1 patient to report improvement in EQ-5D-LSS
- 31 (95% CI 20-72)
Baseline EQ-5D dimensions: no / slight / moderate or greater problem
- Mobility
- 37%, 30%, 33%
- Self-care
- 67%, 20%, 13%
- Usual activities
- 40%, 33%, 27%
- Pain/discomfort
- 45%, 32%, 23%
- Anxiety/depression
- 57%, 27%, 16%
Original publication
EuroQol 5-Dimension Questionnaire in Heart Failure With Reduced, Mildly Reduced, and Preserved Ejection Fraction. JACC Heart Fail. doi:10.1016/j.jchf.2024.10.020
Summarised from the published abstract; every number is checked against it