Secondary analysis
Evaluating Mitral TEER in the Management of Moderate Secondary Mitral Regurgitation Among Heart Failure Patients
- Secondary analysis of the EXPAND and EXPAND G4 studies
- subgroup comparison
- echocardiographic core laboratory assessment
Authors' conclusion
In the EXPANDed studies, subjects with moderate SMR treated with M-TEER had improvements similar to subjects with severe SMR in quality of life and positive LV remodeling at 1 year.
Study context
- Population
- Heart failure (HF) patients with secondary mitral regurgitation treated with mitral transcatheter edge-to-edge repair (MitraClip)
- Participants
- 335 vs 525
- Comparison
- Mitral transcatheter edge-to-edge repair (M-TEER) in moderate secondary mitral regurgitation (SMR) vs severe SMR
- Moderate SMRn = 335
- Severe SMRn = 525reference
- Primary endpoint
- Safety and effectiveness of M-TEER
- Follow-up
- 1 year
Primary result
As reported in the abstract
Left ventricular (LV) end-diastolic and end-systolic volumes decreased on average in moderate SMR
>20 mL
NYHA class I or II in moderate SMR
>78%
KCCQ-Overall Summary improvement in moderate SMR
>20 points
Safety
Major adverse events, all-cause mortality, HF hospitalizations · 1 year
- Low rates, similar between the 2 subgroups
Original publication
Evaluating Mitral TEER in the Management of Moderate Secondary Mitral Regurgitation Among Heart Failure Patients. JACC Heart Fail. Published 11 September 2024. doi:10.1016/j.jchf.2024.08.001
Summarised from the published abstract; every number is checked against it