Valvular & structural heart diseaseRandomised controlled trial
Evaluating the use of proactive surveillance and remote patient monitoring to guide the timing of valve intervention in patients with severe asymptomatic aortic stenosis (APRAISE-AS): results of a pilot randomised controlled trial
- open-label, two-arm, parallel group randomised controlled pilot trial
- 12-month
- two tertiary cardiac centres
- randomly assigned (1:1)
Authors' conclusion
Remote monitoring of severe asymptomatic AS can be safely delivered in practice. Although the pilot did not recruit to target, a digitally enabled clinical pathway to optimise the management of asymptomatic severe AS is acceptable to clinicians and patients.
Study context
- Population
- Participants (≥18 years) with asymptomatic severe aortic stenosis (AS)38/66 participants randomised
- Participants
- 38 participants
- Comparison
- APRAISE-AS intervention in addition to standard care vs standard care
- standard caren = 19
- standard care plus the APRAISE-AS interventionn = 19
Further findings
Adherence to remote monitoring assessments
- weekly symptom assessments
- 81%
- fortnightly timed up and go tests
- 91%
- monthly health-related quality of life assessments (Kansas City Cardiomyopathy Questionnaire (KCCQ))
- 93%
Clinical review and onward referral for valve replacement
- Triggered by a change from baseline in symptoms and KCCQ scores
Original publication
Evaluating the use of proactive surveillance and remote patient monitoring to guide the timing of valve intervention in patients with severe asymptomatic aortic stenosis (APRAISE-AS): results of a pilot randomised controlled trial. Heart. Published 25 August 2026. doi:10.1136/heartjnl-2026-327782
Summarised from the published abstract; every number is checked against it